The prospect of using cell-based interventions to treat neurological conditions raises several important ethical and policy questions. In this target article, we focus on issues related to the unique constellation of traits that characterize CBIs targeted at the central nervous system. In particular, there is at least a theoretical prospect that these cells will alter the recipients' cognition, mood, and behavior—brain functions that are central to our concept of the self. The potential for such changes, although perhaps remote, is cause (...) for concern and careful ethical analysis. Both to enable better informed consent in the future and as an end in itself, we argue that early human trials of CBIs for neurological conditions must monitor subjects for changes in cognition, mood, and behavior; further, we recommend concrete steps for that monitoring. Such steps will help better characterize the potential risks and benefits of CBIs as they are tested and potentially used for treatment. (shrink)

If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

There is a lack of consensus on whether the derivation and use of human embryonic stem cells (hESCs) from embryos remaining after infertility treatment morally require the informed consent of third-party gamete donors who contributed to the creation of the embryos. The principal guidelines for oversight and funding of hESC research in the United States make minimal or no demands for consent from gamete donors. In this article, I consider the arguments supporting and opposing gamete donor consent for hESC research (...) and embryo research more broadly. I argue that it is not morally permissible to use leftover embryos in research without the informed consent of gamete donors, and that we should place restrictions on the use of existing hESC lines that may have been derived without informed consent. While the standard argument for this position relies on an appeal to gamete donors’ interest in controlling what happens with their genetic material, I identify shortcomings with the standard approach and seek instead to locate the deeper moral foundations for gamete donor consent in rights to bodily integrity. (shrink)

We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)

How do artifacts get their functions? It is typically thought that an artifact’s function depends on its maker’s intentions. This chapter argues that this common understanding is fatally flawed. Nor can artifact function be understood in terms of current uses or capacities. Instead, it proposes that we understand artifact function on the etiological model that Ruth Millikan and others have proposed for the biological realm. This model offers a robustly normative conception of function, but it does so naturalistically by employing (...) our best scientific theories, in particular natural selection. To help make this case, it proposes “living artifacts” (organisms designed for human purposes through artificial selection) as a bridge between the artifactual and the biological realms. (shrink)

Rudolf Carnap is widely regarded as one of the most important philosophers of the twentieth century. Born in Germany and later a US citizen, he was a founder of the philosophical movement known as Logical Empiricism. He was strongly influenced by a number of different philosophical traditions, and also by the German Youth Movement, the First World War, and radical socialism. This book places his central ideas in a broad cultural, political and intellectual context, showing how he synthesised many different (...) currents of thought to achieve a philosophical perspective that remains strikingly relevant in the twenty-first century. Its rich account of a philosopher's response to his times will appeal to all who are interested in the development of philosophy in the twentieth century. (shrink)

This article falls into two parts: the first is an analysis, in the light of my earlier discussions of and of the Homeric usage of and the second, an attempt to show that, as in the case of the effects of Homeric usage persist to a considerable degree in the moral philosophy of Aristotle. In the earlier discussions I have argued that the higher value placed upon the competitive in Greek entails that co-operative relationships, even when valued and necessary, take (...) the form dictated by the more valued qualities, the The most general words to denote co-operative relationships in Greek are and its derivatives: my purpose here is to show how the Homeric usage of these words is related to the Homeric standard and to Homeric society, and to sketch in the outline of a wider discussion, which I hope to be able to fill in later. (shrink)

This article falls into two parts: the first is an analysis, in the light of my earlier discussions of and of the Homeric usage of and the second, an attempt to show that, as in the case of the effects of Homeric usage persist to a considerable degree in the moral philosophy of Aristotle. In the earlier discussions I have argued that the higher value placed upon the competitive in Greek entails that co-operative relationships, even when valued and necessary, take (...) the form dictated by the more valued qualities, the The most general words to denote co-operative relationships in Greek are and its derivatives: my purpose here is to show how the Homeric usage of these words is related to the Homeric standard and to Homeric society, and to sketch in the outline of a wider discussion, which I hope to be able to fill in later. (shrink)

In this essay, we aim to provide an overview of the political and philosophical issues pertaining to asexuality. The first section, “What Is Asexuality?,” offers an account of asexuality. The second section, “Asexuality as a Unique Sexual Orientation,” argues that asexuality should be understood as a unique sexual orientation. The third section, “Asexuality and Oppression,” discusses the various forms of oppression facing asexual persons today. The fourth section, “The Goods of Asexuality,” articulates some goods that asexuality brings to human lives, (...) and we do this with an eye toward conceiving of asexuality as something other than a mere deficit. (shrink)

Although a common clinical phenomenon, delusions are difficult to explain and have a problematic conceptual status. Advances in understanding delusions have come from studies which involve detailed investigation of particular types of delusion. Some of this work is summarised, with the Capgras and Cotard delusions as specific examples. These are used to high-highlight questions for which there is the potential for fruitful dialogue with philosophers. Such questions include the criteria for deciding that a statement represents a belief, the extent to (...) which we integrate our beliefs into a coherent web, and the nature and limits of human rationality. (shrink)

This book is concerned with the history of metaphysics since Descartes. Taking as its definition of metaphysics 'the most general attempt to make sense of things', it charts the evolution of this enterprise through various competing conceptions of its possibility, scope, and limits. The book is divided into three parts, dealing respectively with the early modern period, the late modern period in the analytic tradition, and the late modern period in non-analytic traditions. In its unusually wide range, A. W. Moore's (...) study refutes the tired old cliché that there is some unbridgeable gulf between analytic philosophy and philosophy of other kinds. It also advances its own distinctive and compelling conception of what metaphysics is and why it matters. Moore explores how metaphysics can help us to cope with continually changing demands on our humanity by making sense of things in ways that are radically new. (shrink)

This article falls into two parts: the first is an analysis, in the light of my earlier discussions of and of the Homeric usage of and the second, an attempt to show that, as in the case of the effects of Homeric usage persist to a considerable degree in the moral philosophy of Aristotle. In the earlier discussions I have argued that the higher value placed upon the competitive in Greek entails that co-operative relationships, even when valued and necessary, take (...) the form dictated by the more valued qualities, the The most general words to denote co-operative relationships in Greek are and its derivatives: my purpose here is to show how the Homeric usage of these words is related to the Homeric standard and to Homeric society, and to sketch in the outline of a wider discussion, which I hope to be able to fill in later. (shrink)

This book explores for the first time an idea common to both Plato and Aristotle: although people are separate, their lives need not be; one person's life may overflow into another's, so that helping someone else is a way of serving oneself. Price considers how this idea unites the philosophers' treatments of love and friendship (which are otherwise very different), and demonstrates that this view of love and friendship, applied not only to personal relationships, but also to the household and (...) even the city-state, promises to resolve the old dichotomy between egoism and altruism. (shrink)

Lifestyle diseases constitute an increasing proportion of health problems and this trend is likely to continue. A better understanding of the responsibility argument is important for the assessment of policies aimed at meeting this challenge. Holding individuals accountable for their choices in the context of health care is, however, controversial. There are powerful arguments both for and against such policies. In this article the main arguments for and the traditional arguments against the use of individual responsibility as a criterion for (...) the distribution of scarce health resources will be briefly outlined. It is argued that one of the most prominent contemporary normative traditions, liberal egalitarianism, presents a way of holding individuals accountable for their choices that avoids most of the problems pointed out by the critics. The aim of the article is to propose a plausible interpretation of liberal egalitarianism with respect to responsibility and health care and assess it against reasonable counter-arguments. (shrink)

This article outlines the issues addressed by feminist philosophy of art, critically surveys major developments in the field, and concludes by considering directions in which the field is moving.

This paper will discuss the behaviour of and in the Homeric poems. These words are allotted a variety of different ‘meanings’ by the lexicographers. For example, LSJ s.v. I. pray, II. vow, III. profess loudly, boast, vaunt; s.v. I. prayer, II. boast, vaunt, or object of boasting, glory; s.v. I. thing prayed for, object of prayer, II. boast, vaunt. I shall, of course, discuss the whole range of these words; but I begin with some observations on ‘prayer’. It may appear (...) at first sight that ‘prayer’ is a simple word, with only one conceivable ‘meaning’, which must have that ‘meaning’ in any language. We might suggest that ‘request addressed to a god’ is an adequate representation of that ‘meaning’, and that when we have rendered by ‘pray’ in what appear to us to be appropriate contexts we have conveyed the full sense of the original. (shrink)

"A consistently clear, comprehensive and accessible introduction which carefully sifts Foucault's work for both its strengths and weaknesses. McHoul and Grace show an intimate familiarity with Foucault's writings and a lively, but critical engagement with the relevance of his work. A model primer." -Tony Bennett, author of Outside Literature In such seminal works as Madness and Civilization, Discipline and Punish , and The History of Sexuality , the late philosopher Michel Foucault explored what our politics, our sexuality, our societal conventions, (...) and our changing notions of truth told us about ourselves. In the process, Foucault garnered a reputation as one of the pre-eminent philosophers of the latter half of the twentieth century and has served as a primary influence on successive generations of philosophers and cultural critics. With A Foucault Primer , Alec McHoul and Wendy Grace bring Foucault's work into focus for the uninitiated. Written in crisp and concise prose, A Foucault Primer explicates three central concepts of Foucauldian theory-discourse, power, and the subject-and suggests that Foucault's work has much yet to contribute to contemporary debate. (shrink)

As earthquakes expose geological faults, so mental conflict reveals tendencies to rupture within the mind. Dissension is rife not only between people but also within them, for each of us is subject to a contrariety of desires, beliefs, motivations, aspirations. What image are we to form of ourselves that might best enable us to accept the reality of discord, or achieve the ideal of harmony? Greek philosophers offer us a variety of pictures and structures intended to capture the actual and (...) the possible either within a reason that fails to be resolute, or within a split soul that houses a play of forces. Reflection upon them alerts us to the elusiveness at once of mental reality, and of the understanding by which we hope to capture and transform it. Studying in turn the treatments of _Mental Conflict_ in Socrates, Plato, Aristotle and the Stoics, A.W. Price demonstrates how the arguments of the Greeks are still relevant to philosophical discussion today. (shrink)

How, if at all, are we to distinguish between the works that we call ‘art’ and those that we call ‘pornography’? This question gets a grip because from classical Greek vases and the frescoes of Pompeii to Renaissance mythological painting and sculpture to Modernist prints, the European artistic tradition is chock-full of art that looks a lot like pornography. In this paper I propose a way of thinking about the distinction that is grounded in art historical considerations regarding the function (...) of erotic images in 16 th -century Italy. This exploration suggests that the root of the erotic art/pornography distinction was—at least in this context—class: in particular, the need for a special category of unsanctioned illicit images arose at the very time when print culture was beginning to threaten elite privilege. What made an erotic representation exceed the boundaries of acceptability, I suggest, was not its extreme libidinosity but, rather, its widespread availability and, thereby, its threat to one of the mechanisms of sustaining class privilege. (shrink)